Ludo Van Den Bosch Selected Research

Histone Deacetylase 6

1/2021	HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
1/2021	Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
1/2019	Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.
1/2018	Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth.
1/2018	HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
1/2017	Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane- or Cycloheptane-Annulated 1,5-Benzothiazepine Scaffold.
2/2016	Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease.
8/2012	Charcot-Marie-Tooth disease: emerging mechanisms and therapies.

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Ludo Van Den Bosch Research Topics

Disease

37	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2022 - 06/2003
19	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2022 - 06/2004
8	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 12/2022 - 04/2008
7	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 04/2008
5	Disease Progression 01/2021 - 11/2018
5	Neoplasms (Cancer) 01/2018 - 11/2013
5	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/2018 - 06/2004
4	Motor Neuron Disease (Primary Lateral Sclerosis) 12/2019 - 10/2004
4	Peripheral Nervous System Diseases (PNS Diseases) 01/2018 - 08/2012
3	Atrophy 01/2019 - 08/2003
3	Body Weight (Weight, Body) 01/2017 - 08/2003
2	Stroke (Strokes) 01/2022 - 09/2007
2	Multiple Sclerosis 01/2022 - 01/2018
2	Fragile X Syndrome (Martin Bell Syndrome) 01/2021 - 01/2019
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 04/2011
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2020 - 01/2020
2	Alzheimer Disease (Alzheimer's Disease) 12/2019 - 12/2010
2	Sarcoma (Soft Tissue Sarcoma) 12/2019 - 01/2019
2	Paralysis (Palsy) 01/2019 - 01/2005
2	Type 2F Charcot-Marie-Tooth disease 02/2016 - 06/2004
2	Inflammation (Inflammations) 01/2016 - 11/2013
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Proteostasis Deficiencies 10/2021
1	Demyelinating Diseases (Demyelinating Disease) 01/2021
1	Type 2A Charcot-Marie-Tooth disease 01/2021
1	Muscle Weakness 01/2021
1	Sepsis (Septicemia) 01/2021
1	Myotonic Dystrophy (Dystrophia Myotonica) 01/2020
1	Huntington Disease (Huntington's Disease) 01/2020
1	Fragile X Tremor Ataxia Syndrome 01/2020
1	Wounds and Injuries (Trauma) 06/2019
1	Rare Diseases (Rare Disease) 01/2019
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2018
1	Parkinson Disease (Parkinson's Disease) 01/2018
1	Central Nervous System Diseases (CNS Diseases) 01/2018
1	Pathological Protein Aggregation 09/2017

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 05/2022 - 06/2004
9	DNA-Binding Proteins (DNA Binding Protein)IBA 12/2022 - 09/2012
8	Histone Deacetylase 6IBA 01/2021 - 08/2012
6	ProgranulinsIBA 01/2017 - 04/2008
6	AMPA Receptors (AMPA Receptor)IBA 12/2010 - 06/2003
4	Superoxide Dismutase-1IBA 01/2019 - 03/2005
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2007 - 10/2004
3	CalciumIBA 01/2021 - 02/2010
3	propionic acid (potassium propionate)IBA 12/2010 - 06/2003
2	Histone Deacetylases (Histone Deacetylase)IBA 10/2021 - 01/2021
2	Phosphotransferases (Kinase)IBA 01/2021 - 01/2020
2	SW-100IBA 01/2021 - 01/2019
2	DipeptidesIBA 12/2020 - 10/2019
2	RNA (Ribonucleic Acid)IBA 01/2020 - 12/2019
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2018 - 01/2016
2	Pharmaceutical PreparationsIBA 01/2017 - 04/2016
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2013 - 12/2010
2	IonsIBA 12/2010 - 09/2007
2	Small Heat-Shock ProteinsIBA 08/2010 - 06/2004
1	Interleukin-2 (IL2)IBA 01/2022
1	LipidsIBA 10/2021
1	ConnectinIBA 01/2021
1	1,2,3,4-tetrahydroquinolineIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	Myosins (Myosin)IBA 01/2021
1	1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA 12/2020
1	polyglutamineIBA 01/2020
1	NucleotidesIBA 01/2020
1	Amyloid (Amyloid Fibrils)IBA 12/2019
1	EphrinsIBA 12/2019
1	Biomarkers (Surrogate Marker)IBA 12/2019
1	Ephrin-A5 (AL-1)IBA 12/2019
1	CytokinesIBA 06/2019
1	Interleukin-33IBA 06/2019
1	metabotropic glutamate receptor type 1IBA 01/2019
1	Glutamate Receptors (Glutamate Receptor)IBA 01/2019
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2019
1	Jagged-1 ProteinIBA 11/2018
1	DNA (Deoxyribonucleic Acid)IBA 11/2018
1	Cell Cycle ProteinsIBA 01/2018
1	TubulinIBA 01/2018
1	Vinca AlkaloidsIBA 01/2018
1	Vincristine (Oncovin)FDA LinkGeneric 01/2018
1	Glycine-tRNA LigaseIBA 01/2018
1	Arginine (L-Arginine)FDA Link 03/2017
1	Tamoxifen FDA LinkGeneric 01/2017
1	ricolinostatIBA 01/2017
1	AndrogensIBA 01/2017
1	Pioglitazone (Actos)FDA Link 04/2016
1	AdiponectinIBA 04/2016
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 04/2016
1	EnzymesIBA 04/2016
1	Peptides (Polypeptides)IBA 04/2016
1	MelanocortinsIBA 04/2016
1	tubastatin AIBA 02/2016
1	LipopolysaccharidesIBA 01/2016

Therapy/Procedure

9	Therapeutics 01/2021 - 08/2012
2	Ligation 01/2021 - 11/2018
1	Denervation 01/2021
1	Punctures 01/2021
1	Treatment Delay 06/2019
1	Muscle Denervation 01/2019
1	Drug Therapy (Chemotherapy) 01/2018